Prof. Changbin Shi
Department
of Neurosurgery
Harbin
Medical University, China
Professor
Department
of Surgery
The
University of Chicago, USA
Assistant
Professor
Email: cshi@surgery.bsd.uchicago.edu, changbinshi@uchicago.edu
Qualifications
2002-2006 Ph.D., Lund
University, Sweden, Surgery and Hematopoietic Stem Cell Biology
2001-2002 Senior
Visiting Scholar, Kansai Medical University, Japan, Neurosurgery and Microbiology
1998-2000 M.Sc., Harbin
Medical University, China, Neurosurgery
1981-1986
M.D. & B.S., Harbin Medical University, China
Publications
(Selected)
-
Shi
C, Zhao X, Lagergren A, Sigvardsson M, Wang XD, Andersson R. 2006. Immune
status and inflammatory response differ locally and systemically in severe
acute pancreatitis. Scand J Gastroenterol 41: 472-480.
-
Zhao
X, Shi C, Wang XD, Andersson R. 2006. Protein kinase C modulates the pulmonary
inflammatory response in acute pancreatitis. Respir Physiol Neurobiol 152:
16-26.
-
Shi
C, Zhao X, Wang XD, Zhao L, Andersson R. 2007. Potential effects of PKC or
protease inhibitors on acute pancreatitis-induced tissue injury in rats. Vascul
Pharmacol 46: 406-411.
-
Shi
C, Shenkar R, Batjer HH, Check IJ, Awad IA. 2007. Oligoclonal immune response
in cerebral cavernous malformations. Laboratory investigation. J Neurosurg 107:
1023-1026.
-
Shenkar
R, Venkatasubramanian PN, Wyrwicz AM, Zhao J, Shi C, Akers A, Marchuk DA, Awad
IA. 2008. Advanced magnetic resonance imaging of cerebral cavernous
malformations: Part II. Imaging of lesions in murine models. Neurosurgery
63:790-797.
-
Shi
C, Awad IA, Jafari N, Lin S, Du P, Hage ZA, Shenkar R, Getch CC, Bredel M,
Batjer HH, Bendok BR. 2009. Genomics of human intracranial aneurysm wall.
Stroke 40: 1252-61.
-
Shi
C, Shenkar R, Du H, Duckworth E, Raja H, Batjer HH, Awad IA. 2009. Immune
response in human cerebral cavernous malformations. Stroke 40: 1659-65.
-
Zheng
B, Zheng T, Wang L, Chen X, Shi C*, Zhao S. 2010. Aminoguanidine inhibition of
iNOS activity ameliorates cerebral vasospasm after subarachnoid hemorrhage in
rabbits via restoration of dysfunctional endothelial cells. J Neurol Sci. 295:
97-103. [*co-corresponding author]
-
Zheng
B, Qiu Y, Jin H, Wang L, Chen X, Shi C*, Zhao S. 2011. A predictive value of
hyponatremia for poor outcome and cerebral infarction in high-grade
aneurysmal subarachnoid hemorrhage patients. J Neurol Neurosurg
Psychiatry 82: 213-7. [*co-corresponding author]
-
Liu
Y, Zhang X, Liang Y, Yu H, Chen X, Zheng T, Zheng B, Wang L, Zhao L, Shi C,
Zhao S. 2011. Targeting XBP1 Enhances Sensitivity of Glioma Cells to Oxidative
Stress. Neuropathol Appl Neurobiol 37: 395-405.
-
McDonald
DA, Shenkar R*, Shi C*, Stockton RA, Akers AL, Kucherlapat MH, Kucherlapati R,
Brainer J, Ginsberg MH, Awad IA, and Marchuk DA. 2011. A novel mouse model of
cerebral cavernous malformations based on the two-hit mutation hypothesis
recapitulates the human disease. Hum Mol Genet 20: 211-22. [*co-2nd author]
-
Liu
Y, Liang Y, Zheng T, Yang G, Zhang X, Sun Z, Shi C, Zhao S. 2011. Inhibition of
heme oxygenase-1 enhances anti-cancer effects of arsenic trioxide on glioma
cells. J Neurooncol 104: 449-58.
-
Yang
G, Zhang R, Chen X, Mu Y, Ai J, Shi C, Liu Y, Shi C, Sun L, Rainov NG, Li H,
Yang B, Zhao S. 2011. MiR-106a inhibits glioma cell growth by targeting E2F1
independent of p53 status. J Mol Med (Berl) 89: 1037-50.
-
McDonald
DA*, Shi C*, Shenkar R, Stockton RA, Liu F, Ginsberg MH, Marchuk DA, Awad IA.
2012. Fasudil Decreases Lesion Burden in a Murine Model of Cerebral Cavernous
Malformation Disease. Stroke. 43: 571-4. [*co-1st author]
-
Zhao
S, Chen X, Wang L, Yang G, Han D, Teng L, Yang M, Wang D, Shi C, Liu Y, Zheng
B, Shi C, Gao X, Rainov NG. 2013. Increased Expression of ABCB6 Enhances
Protoporphyrin IX Accumulation and Photodynamic Effect in Human Glioma. Ann
Surg Oncol. 20: 4379-88.
-
Zhao
S, Yang G, Mu Y, Han D, Shi C, Chen X, Zhang D, Deng Y, Wang L, Liu Y, Hou X,
Wang C, Wu J, Wang L, Liu H, Zhang G, Qi J, Fang X, Shi C, Ai J. 2013. MiR-106a
is an independent prognostic marker in patients with glioblastoma. Neuro Oncol.
15: 707-17.
-
Wu
J, Ji Z, Liu H, Liu Y, Han D, Shi C, Shi C, Wang C, Yang G, Chen X, Shen C, Li
H, Bi Y, Zhang D, Zhao S. 2013. Arsenic trioxide depletes cancer stem-like
cells and inhibits repopulation of neurosphere derived from glioblastoma by
downregulation of Notch pathway. Toxicol Lett. 220: 61-9.
-
Mikati
AG, Tan H, Shenkar R, Li L, Zhang L, Guo X, Larsson HB, Shi C, Liu T, Wang Y,
Shah A, Edelman RR, Christoforidis G, Awad I. 2013. Dynamic Permeability and
Quantitative Susceptibility: Related Imaging Biomarkers in Cerebral Cavernous
Malformations. Stroke. 45: 598-601.
-
Yang
G, Chen X, Li CG, Zhang DM, Zhang WG, Shi C, Zhao SG. 2013. Multiple
meningiomas characterized by benign and malignant tumor entities. CNS Neurosci
Ther. 19: 984-6.
-
Yang
G, Han D, Chen X, Zhang D, Wang L, Shi C, Zhang W, Li C, Chen X, Liu H, Zhang
D, Kang J, Peng F, Liu Z, Qi J, Gao X, Ai J, Shi C, Zhao S. 2014. MiR-196a
exerts its oncogenic effect in glioblastoma multiforme by inhibition of IkBa
both in vitro and in vivo. Neuro Oncol. 16: 652-61.
-
Tan
H, Liu T, Wu Y, Thacker J, Shenkar R, Mikati AG, Shi C, Dykstra C, Wang Y,
Prasad PV, Edelman RR, Awad IA. 2014. Evaluation of iron content in human
cerebral cavernous malformation using quantitative susceptibility mapping.
Invest Radiol. 49: 498-504.
-
McDonald
DA, Shi C, Shenkar R, Gallione CJ, Akers AL, Li S, De Castro N, Berg MJ,
Corcoran DL, Awad IA, Marchuk DA. Lesions from patients with sporadic cerebral
cavernous malformations harbor somatic mutations in the CCM genes: evidence for
a common biochemical pathway for CCM pathogenesis. Hum Mol Genet. 2014. [Epub
ahead of print]
-
Shi
C, Shenkar R, Kinloch A, Henderson SG, Shaaya M, Chong AS, Clark MR, Awad IA.
2014. Immune complex formation and in situ B-cell clonal expansion in human
cerebral cavernous malformations. J Neuroimmunol. 272: 67-75.
-
Shenkar
R, Shi C, Rebeiz T, Stockton RA, McDonald DA, Mikati AG, Zhang L, Austin C,
Akers AL, Gallione CJ, Rorrer A, Gunel M, Min W, Marcondes de Souza J, Lee C,
Marchuk DA, Awad IA. Exceptional aggressiveness of cerebral cavernous
malformation disease associated with PDCD10 mutations. Genet Med.
2015;17:188-96. [*co-1st author]
-
Na
M, Liu Y, Shi C, Gao W, Ge H, Wang Y, Wang H, Long Y, Shen H, Shi C, Lin Z.
2014. Prognostic value of CA4/DG volumetry with 3T magnetic resonance imaging
on postoperative outcome of epilepsy patients with dentate gyrus pathology.
Epilepsy Research. 108: 1315-25.