Prof. Mitsuharu Yoshiyama
Department of Urology
Interdisciplinary Graduate School of Medicine and Engineering
University of Yamanashi, Japan
Research Professor
E-mail: PXN15164@nifty.ne.jp
Qualifications
1993 Ph.D., Graduate School of Medicine, Showa University, Japan
1989 M.D., School of Medicine, Showa University, Japan
Publications (Selected)
-
Yoshiyama, M., Roppolo, J. R., Takeda, M., de Groat, W. C. Effects of urethane on reflex activity of lower urinary tract in decerebrate unanesthetized rats. Am. J. Physiol. Renal Physiol. 304: F390-F396, 2013.
-
Zakoji, H., Kobayashi, H., Yoshiyama, M., Takeda, M., Araki, I. Expression of large conductance, voltage- and Ca2+-activated K+ (BK) channels in human urinary bladder: alteration of subunit expression profile in association with bladder outlet obstruction. Open J. Urol. 3:47-52, 2013.
-
Kamiyama, M., Fukasawa, M., Takihana, Y., Sawada, N., Nakagomi, H., Yoshiyama, M., Araki, I., Takeda, M. Distribution and possible function of cannabinoid receptor subtype 1 in the human prostate. Open J. Urol. 3: 102-109, 2013.
-
Yoshiyama, M., Mochizuki, T., Nakagomi, H., Miyamoto, T., Kira, S., Mizumachi, R., Sokabe, T., Takayama, Y., Tominaga, M., Takeda, M. Functional roles of TRPV1 and TRPV4 in control of lower urinary tract activity: dual analysis of behavior and reflex during the micturition cycle. Am. J. Physiol. Renal Physiol. 308: F1128-F1134, 2015.
-
Beppu, M., Araki, I., Yoshiyama, M., Du, S., Kobayashi, H., Zakoji, H., and Takeda, M. Bladder Outlet Obstruction-Induced Expression of Prostaglandin E2 Receptor Subtype EP4inthe Rat Urinary Bladder: a Possible Counteractive Mechanism against Detrusor Overactivity. J. Urol.186: 2463-2469, 2011.
-
Takeda, M., Mochizuki, T., Yoshiyama, M., Nakagomi, H., Kobayashi, H., Sawada, N., Zakohji, H., Du, S., Araki, I. Sensor mechanism and afferent signal transduction of the urinary bladder: special focus on transient receptor potential ion channels. LUTS (Lower Urinary Tract Symptoms) 2: 51-60, 2010.
-
Araki, I., Yoshiyama, M., Kobayashi, H., Mochizuki, T., Du, S., Okada, Y. and Takeda, M. Emerging families of ion channels involved in urinary bladder nociception. Pharmaceuticals 3: 2248-2267, 2010.
-
Yoshiyama, M., Araki, I., Kobayashi, H., Zakoji, H. and Takeda, M. Functional roles of TRPV1 channels in lower urinary tract irritated by acetic acid: in vivo evaluations of the sex difference in decerebrate unanesthetized mice. Am. J. Physiol. Renal. Physiol. 298: F1351-F1359, 2010.
-
Uchiyama, T., Sakakibara, R., Yoshiyama, M., Yamamoto, T., Ito, T., Liu, Z., Yamaguchi, C., Awa, Y., Yano, H.-M., Yanagisawa, M., Yamanishi, T., Hattori, T. and Kuwabara, S. Biphasic effect of apomorphine, an anti-parkinsonian drug, on bladder function in rats. Neuroscience 162:1333-1338, 2009.
-
Kobayashi, H., Yoshiyama, M., Zakoji, H., Takeda, M. and Araki, I. Sex differences in the expression profile of acid-sensing ion channels in the mouse urinary bladder: a possible involvement in irritative bladder symptoms. BJU Int. 104:1746-1751, 2009.
-
Yoshiyama, M. Glutamatergic mechanisms controlling lower urinary tract function. LUTS (Lower Urinary Tract Symptoms) 1:S101-S104, 2009.
-
Kakizaki, H. and Yoshiyama, M. Role of central 5-hydroxytrypyamine receptors in micturition control. LUTS (Lower Urinary Tract Symptoms) 1:S36-S39, 2009.
-
Araki, I., Du, S., Kobayashi, H., Yoshiyama, M. and Takeda, M. Mechanosensitive ion channels in bladder sensory transduction. LUTS (Lower Urinary Tract Symptoms) 1:S18-S21, 2009.
-
Yoshiyama, M. and de Groat, W.C. The role of vasoactive intestinal polypeptide and pituitary adenylate cyclase-activating polypeptide in the neural pathways controlling the lower urinary tract. J. Mol. Neurosci. 36:227-240, 2008.
-
Yoshiyama, M., Kobayashi, H., Araki, I., Du, S., Zakoji, H. and Takeda, M. Sex-related differences in activity of lower urinary tract in response to intravesical acid irritation in decerebrate unanesthetized mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 295:R954-R960, 2008.
-
Yoshiyama, M. and de Groat, W.C. Effects of intrathecal administration of pituitary adenylate cyclase activating polypeptide on lower urinary tract functions in rats with intact or transected spinal cords. Exp. Neurol. 211:449-455, 2008.