Enzyme Kinetic Equations of Irreversible and Reversible Reactions in Metabolism ()
Abstract
This paper compares the irreversible and
reversible rate equations from several uni-uni kinetic mechanisms (Michaelis-Menten,
Hill and Adair equations) and bi-bi mechanisms (single- and double- displacement
equations). In reversible reactions, Haldane relationship is considered to be
identical for all mechanisms considered and reversible equations can be also
obtained from this rela- tionship. Some reversible reactions of the metabolism
are also presented, with their equilibrium constant.
Share and Cite:
Imperial, S. and Centelles, J. (2014) Enzyme Kinetic Equations of Irreversible and Reversible Reactions in Metabolism.
Journal of Biosciences and Medicines,
2, 24-29. doi:
10.4236/jbm.2014.24005.
Conflicts of Interest
The authors declare no conflicts of interest.
References
[1]
|
Alberty, R.A., Cornish-Bowden, A., Goldberg, R.N., Hammes, G.G., Tipton, K. and Westerhoff, H.V. (2011) Reccommendations for Terminology and Databases for Biochemical Thermodynamics. Biophysical Chemistry, 155, 89- 103. http://dx.doi.org/10.1016/j.bpc.2011.03.007
|
[2]
|
Hofmeyr, J.-H.S. and Cornish-Bowden, A. (1997) The Reversible Hill Equation: How to Incorporate Cooperative Enzymes into Metabolic Models. CABIOS, 13, 377-385.
|
[3]
|
King, E.L. and Altman, C. (1956) A Schematic Method of Deriving the Rate Laws for Enzyme-Catalyzed Reactions. The Journal of Physical Chemistry, 60, 1373-1378. http://biokin.com/king-altman/index.html
http://dx.doi.org/10.1021/j150544a010
|
[4]
|
Barman, T.E. (1969) Enzyme Handbook. Springer-Verlag, Berlin. http://dx.doi.org/10.1007/978-3-642-86602-9
|