TITLE:
Regional Coherence Alterations in Patients with Poststroke Cognitive Impairment after Acupuncture Therapy: A Resting-State fMRI Study
AUTHORS:
Peng Zhang, Ran Wang, Yue Shi, Xiao-Hua Huang, Lin Yang
KEYWORDS:
Acupuncture, Post-Stroke Cognitive Impairment, Functional MagneticResonance Imaging, Regional Coherence
JOURNAL NAME:
Health,
Vol.16 No.12,
December
6,
2024
ABSTRACT: Objective: To explore regional homogeneity (ReHo) alterations after acupuncture treatment in poststroke cognitive impairment (PSCI) patients. Methods: Twenty-one PSCI patients who underwent acupuncture therapy in our hospital and 12 matched healthy controls were enrolled in this study. All study subjects underwent resting-state functional magnetic resonance imaging (rs-fMRI); for PSCI patients, rs-fMRI scans were conducted before and after acupuncture therapy. Data preprocessing was performed using the DPARSF5.4 and SPM12 toolkits on the MATLAB 2022b platform. DPARSF5.4 was used to calculate the ReHo index of the preprocessed resting-state data. A two-sample t-test was used to compare the differences in ReHo between the PSCI patients group pretreatment and the control group (with sex and age as covariates), and a paired t-test was used to compare the differences in ReHo between the pretreatment and posttreatment groups of PSCI patients (without covariates). AAL_116_binary_mask.nii was used as the statistical mask, and the statistical results were corrected using family-wise error correction, with P Conclusion: PSCI patients exhibited abnormal ReHo in the resting state, and ReHo was significantly altered after acupuncture treatment. The results of this study suggest that ReHo might be a potential biomarker in the diagnosis and treatment of PSCI.