P. Crepaldi, B. Crepaldi, B. Cacciari, M. C. Bonache, G. Spalluto, K. Varani, P. A. Borea, I. von Kuegelgen, K. Hoffmann, M. Pugliano, C. Razzari and M. Cattaneo, “6-Amino-2-Mercapto-3H-pyrimidin-4-one Derivatives as New Candidates for the Antagonism at the P2Y12 Receptors,” Bioorganic & Medicinal Chemistry, Vol. 17, No. 13, 2009, pp. 4612-4621.
http://dx.doi.org/10.1016/j.bmc.2009.04.061

has been cited by the following article:

• TITLE: Novel Synthesis Approach and Antiplatelet Activity Evaluation of 6-Arylmethyleneamino-2-Alkylsulfonylpyrimidin-4(3H)-one Derivatives and Its Nucleosides

  AUTHORS: Abdulrahman G. Alshammari, Abdel-Rhman B. A. El-Gazzar

  KEYWORDS: Natural Asset; Financial Value; Neural Network

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.3 No.3A, November 6, 2013

  ABSTRACT: A new and efficient procedure has been designed for the preparation of 6-arylmethylene-amino-2-alkyl sulfonyl-pyrimidine. The first alkylthio group was introduced into the pyrimidine ring by S-alkylation. The introduction of the second one was successfully achieved using the phosphorous oxychloride method to afford 4-chloro-2-alkylthio-pyrimidines. Subsequent nucleophilic displacement by the corresponding alkylamines followed by glycoside bromide addition conveniently gave a series of the target compounds. Thus, the two same or different alkylamino groups were easily introduced into the pyrimidine ring through the two different approaches. The human anti-platelet aggregation activity of the newly synthesized compounds was also described.