TITLE:
Stimulatory Effect of Whole Coffee Fruit Concentrate Powder on Plasma Levels of Total and Exosomal Brain-Derived Neurotrophic Factor in Healthy Subjects: An Acute Within-Subject Clinical Study
AUTHORS:
Tania Reyes-Izquierdo, Ruby Argumedo, Cynthia Shu, Boris Nemzer, Zb Pietrzkowski
KEYWORDS:
Brain-Derived Neurotrophic Factor; Whole Coffee Fruit Concentrate; Coffee; Exosomes; Acute Effect
JOURNAL NAME:
Food and Nutrition Sciences,
Vol.4 No.9,
August
30,
2013
ABSTRACT:
A pilot study by Reyes [1] previously showed that ingestion of single dose of whole
coffee fruit concentrate (WCFC) powder increased blood levels of brain derived
neurotrophic factor (BDNF) during the first 60 minutes after ingestion. In the
present report, we
performed a single dose, placebo-controlled, within-subject study to confirm
and further investigate this effect. Twenty healthy subjects with ages ranging
from 25 to 35 participated in this study. All fasted and resting subjects
received placebo on Day 1, WCFC on Day 2, and a cup of freshly brewed coffee on
Day 3. Treatment with WCFC resulted in a statistically significant increase in
plasma BDNF compared to placebo (p = 0.0073) or coffee
(p = 0.0219) during first 60 minutes. In
addition, e isolated exosomes from serum and found that they contained BDNF. Furthermore,
oral WCFC consumption acutely increased BDNF levels in serum exosomes. In
summary, all presented results justify further clinical investigation of WCFC
as a tool to manage BDNF-dependent health conditions.