TITLE:
Protective effect of maifanite against cadmium-induced oxidative stress to rats hippocampus by regulating the balance and metabolism of metals
AUTHORS:
Hailin Liao, Lingfeng Jiang, Hongmiao Huang, Lixia Zhou, Ling Li, Shixian Cheng
KEYWORDS:
Maifanite; Cd Toxicity; Oxidative Stress; Metallothionein; Trace Element
JOURNAL NAME:
Health,
Vol.5 No.9,
August
28,
2013
ABSTRACT:
In this paper, the
author reported the effect of maifanite on the learning and
memory of rats suffering Cd poisoning by step-down and step-through test, analyzed the content of MDA, MT, SOD, and GSH-Px in the hippocampus of rats respectively, and assayed the
content of Fe, Cu, Zn, Mn, Se, and Cd in the hippocampus of rats. In
the step-down test, it is found that maifanite can reduce the number of
electric shock, prolong step-down latency,
and cut down error times when rats are exposed to Cd 24 h. In the step-through test, maifanite can obviously prolong the latency of entering the dark cabin of rats suffering Cd poisoning. The
exogenous Cd can lead to the decrease of SOD and GSH-Px activity and the
increase of MDA and MT content. The alternation of maifanite and Cd by the gavage
can significantly increase the SOD and GSH-Px activity as well as MT content, while lessening the MDA content.
The accumulation of exogenous Cd in hippocampus causes the increase of Zn, Fe,
Mn, and Cd content, and the decrease of Cu and Se content. The intake of
maifanite can regulate the imbalance of metals
content and make its content near to the of level control group. The research
shows that maifanite can improve the ability of learning and memory of rats suffering
Cd poisoning, increase MT formation and lower hyperoxidative damage. Maifanite
has the function of balancing the content of trace elements in rats
suffering Cd poisoning, and meanwhile can alleviate the toxicity of
Cd effectively.