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has been cited by the following article:

• TITLE: Protective Effect of Gingo biloba Extract on Carbendazim-Induced Hepatotoxicity in Albino Rats

  AUTHORS: Faiza A. Mahboub, Hawazen A. Lamfon

  KEYWORDS: Carbendazim; Ginko biloba; Hepatotoxicity; Histochemistry; Rats

  JOURNAL NAME: Food and Nutrition Sciences, Vol.4 No.8, August 5, 2013

  ABSTRACT: Carbendazim is a broad spectrum carbamate fungicide used in the control of various fungal pathogens. The present work studied the effect of carbendazim on the liver of albino rats and the possible protective role of Ginko biloba extract (EGB). Liver of carbendazim-treated animals showed histopathological and histochemical alterations. The histopathological changes include hepatic tissue impairment, cytoplasmic vacuolization of the hepatocytes, and congestion of blood vessels, leucocytic infiltrations and fatty infiltration. Histochemical results showed reduction of carbohydrates and total proteins in hepatic tissues. Moreover, liver function enzymes (ALT, AST) were elevated in sera of carbendazim-treated animals. Coadministration of EGB with Carbendazim improved the hisological and histochemical changes observed in animals treated with carbendazim. In addition, EGB treatment leads to a significant decrease in ALT and AST. According to the present results, it is concluded that EGB can improve the hepatotoxicity of carbendazim and this effect may be attributed to antioxidant properties of Ginko biloba extract.