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L. D. Jennings, S. L. Kincaid, Y. D. Wang, G. Krishnamurthy, C. F. Beyer, J. P. McGinnis, M. Miranda, C. M. Discafani and S. K. Rabindran, “Parallel Synthesis and Biological Evaluation of 5,6,7,8-Tetrahydrobenzothieno [2,3-d]pyrimidin-4(3H)-one Cytotoxic Agents Selective for p21-Deficient Cells,” Bioorganic & Medicinal Chemistry Letter, Vol. 15, No. 21, 2005, pp. 4731-4735.
has been cited by the following article:
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TITLE:
Design, Synthesis and Pharmacological Evaluation of New Nonsteroidal Anti-Inflammatory Derived from 3-Aminobenzothieno[2,3-d]pyrimidines
AUTHORS:
Hend Nagah Hafez, Omar Khalid Al-Duaij, Abdel-Rhman Barakat A. El-Gazzar
KEYWORDS:
Spirobenzothienopyrimidine; Triazolopyrimidine; Pyrazolopyrimidine; Analgesic; Anti-inflammatory; Ulcerogenic Effect
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.3 No.2,
June
13,
2013
ABSTRACT:
During the
last few years, condensed thienopyrimidine derivatives have received
considerable attention. The therapeutic importance of thienopyrimidines
prompted us to synthesize some of spiro(benzothieno[2,3-d]pyrimidine-4-one) derivatives. Some of the novel benzothino-pyrimidine
derivatives 3a, 9b,
10b, 11a, 11b, and 11c showed considerable potent
anti-inflammatory and analgesic activity of superior G.I.T. safety profile in
experimental rats in comparing to indomethacin and tramadol as reference drugs.