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A. J. Folkes, K. Ahmadi, W. K. Alderton, S. Alix, S. J. Baker, G. Box, I. S. Chuckowree, P. A. Clarke, P. Depledge, S. A. Eccles, L. S. Friedman, A. Hayes, T. C. Hancox, A. Kugendradas, L. Lensun, P. Moore, A. G. Olivero, J. Pang, S. Patel, G. H. Pergl-Wilson, F. I. Raynaud, A. Robson, N. Saghir, L. Salphati, S. Sohal, M. H. Ultsch, M. Valenti, H. J. A. Wall-weber, N. C. Wan, C. Wiesmann, P. Workman, A. Zhyvoloup, M. J. Zvelebil and S. J. Shuttleworth, “The Identification of 2-(1H-Indazol-4-yl)-6-(4methanesulfonylpiperazin-1-yl-methyl)-4-morpholin-4yl-thie-no[3,2-d]pyrimidine (GDC-0941) as a Potent, Selective, Orally Bioavailable Inhibitor of Class I PI3 Kinase for the Treatment of Cancer,” Journal Medicinal Chemistry, Vol. 51, No. 18, 2008, pp. 5522-5532.
has been cited by the following article:
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TITLE:
Design, Synthesis and Pharmacological Evaluation of New Nonsteroidal Anti-Inflammatory Derived from 3-Aminobenzothieno[2,3-d]pyrimidines
AUTHORS:
Hend Nagah Hafez, Omar Khalid Al-Duaij, Abdel-Rhman Barakat A. El-Gazzar
KEYWORDS:
Spirobenzothienopyrimidine; Triazolopyrimidine; Pyrazolopyrimidine; Analgesic; Anti-inflammatory; Ulcerogenic Effect
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.3 No.2,
June
13,
2013
ABSTRACT:
During the
last few years, condensed thienopyrimidine derivatives have received
considerable attention. The therapeutic importance of thienopyrimidines
prompted us to synthesize some of spiro(benzothieno[2,3-d]pyrimidine-4-one) derivatives. Some of the novel benzothino-pyrimidine
derivatives 3a, 9b,
10b, 11a, 11b, and 11c showed considerable potent
anti-inflammatory and analgesic activity of superior G.I.T. safety profile in
experimental rats in comparing to indomethacin and tramadol as reference drugs.