Article citationsMore>>
E. S. Jordanova, A. Gorter, Ou. Ayachi, F. Prins, L. G. Durrant, G. G. Kenter, S. H. van der Burg and G. J. Fleuren, “Human Leukocyte Antigen Class I, MHC Class I Chain-Related Molecule A, and CD8+/Regulatory T-Cell Ratio: Which Variable Determines Survival of Cervical Cancer Patients?” Clinical Cancer Research, Vol. 14, 2008, pp. 20-28.
has been cited by the following article:
-
TITLE:
The Expression of CD8+ and MHC-I in Cervical Cancer with HPV Infection
AUTHORS:
Adi Prayitno, Elyana Asnar, Okid Parama Astirin, Suhartono Taat Putra
KEYWORDS:
CD8+; MHC-I; HPV; Cervical Cancer
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.4 No.5A,
May
20,
2013
ABSTRACT:
Introduction: The immunity against cervical cancers is many unknown. Major histocompatability complex class I (MHC-I) with the alpha domain has binding site for Cytotoxic T cells (CD8+) to target cells. The objective of this experiment is to know the expression of CD8+ and MHC-I in cervical cancer with HPV infection. Method: DNA was isolated from seventeen sample cervical cancer tissues frozen section. Diagnose related with HPV was made by PCR. Paraffin block of the tissues was cut in thoroughly cleaned cryotome and place in glass plate that covered with poly-elysine. The immuno-histochemistry is done with monoclonal antibody again MHC-I and CD8+ with TSA-indirect method. The power of expression was counted the number of positive cells to express the MHC-I and CD8+ every 100 cells per one view look. Result: The Result of this experiment shows that expression of MHC-I and CD8+ in cervical cancer with HPV infection is in mild category (30% - 70%). Conclusion: Immunity against uterine cancer played by MHC-I and CD8+ is in milt category. The experiment that related with uterine cancer immunology is suggested.
Related Articles:
-
Adi Prayitno, Elyana Asnar, Okid Parama Astirin, Suhartono Taat Putra
-
Yemliha Yildiz, Ilhan Yaylim, Nazli Ezgi Ozkan, Soykan Arikan, Saime Turan, Seden Kucucuk, Ender Coskunpinar, Turgay Isbir
-
Honoré Jean Gabriel Berthé, Dramane Cissé, Moussa Salifou Diallo, Amadou Kassogué, Alkadri Diarra, Mamadou Tidiani Coulibaly, Mamadou Lamine Diakité, Modibo Coulibaly, Mory Koné
-
Karolj Skala, Davor Davidović, Tomislav Lipić, Ivan Sović
-
Sidiki Keita, Koniba Keita, Moussa Sissoko, Mahamadou Coulibaly, Lamine Soumare, Oumar Sacko, Sekou Koumaré, Adama K. Koita, Soumaîla Keita, Zimogo Zié Sanogo