TITLE:
The activities of endothelial elastase and cathepsin G in rats at oxidative stress caused by heavy metals salts
AUTHORS:
Nickolaj F. Starodub, Ljubov M. Samokhina
KEYWORDS:
Endothelial Elastase; Cathepsin G; Cobalt Chloride; Mercury Chloride; Rats
JOURNAL NAME:
Advances in Biological Chemistry,
Vol.3 No.2,
April
30,
2013
ABSTRACT: CoCl2 introduction increased cathepsin
G activity in the heart and liver as well as endothelial elastase (EEl) in kidney that
indicated the development of destructive processes. CoCl2 introduction decreased EEl and cathepsin G activities in blood serum and
cathepsin G in lungs. HgCl2 injection decreased EEl in blood serum,
heart, liver, kidney and cathepsin G in blood serum. These decreasing of
proteinases activities may be caused by cytotoxic effects of heavy metals
and/or the inclusion of these proteases in the destructive processes and absence of their synthesis and/or release.