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J. H. Lange, H. H. Stuivenberg, H. K. Coolen, T. J. Adolfs, A. C. McCreary, H. G. Keizer, H. C. Wals, W.Veerman, A. J. Borst, W. de Looff, P. C. Verveer and C. G. Kruse, “Bioisosteric Replacements of the Pyrazole Moiety of Rimonabant: Synthesis, Biological Properties, and Molecular Modeling Investigations of Thiazoles, Triazoles, and Imidazoles as Potent and Selective CB1 Cannabinoid Receptor Antagonists,” Journal of Medicinal Chemistry, Vol. 48, No. 6, 2005, pp. 1823-1838.
doi:10.1021/jm040843r
has been cited by the following article:
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TITLE:
The Reaction of Cyanoacetylhdrazine with Furan-2-Aldehyde: Novel Synthesis of Thiophene, Azole, Azine and Coumarin Derivatives and Their Antitumor Evaluation
AUTHORS:
Wagnat W. Wardakhan, Sherif M. Sherif, Rafat M. Mohareb, Amr S. Abouzied
KEYWORDS:
Acetylhydrazine; Hydrazide-Hydrazone; Thiophene; Thiazole; Pyridine; Coumarin; Antitumor
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.2 No.4,
December
27,
2012
ABSTRACT: The reaction of cyanoacetylhydrazine 1 with furan-2-aldehyde 2 gives the hydrazide-hydrazone derivative 3. The latter compound undergoes a series of heterocyclization reactions to give new heterocyclic compounds. The antitumor evaluation of the newly synthesized products against three cancer cell lines, namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) were recorded. Some of the synthesized compounds show high inhibitory effects.
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