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has been cited by the following article:

• TITLE: Designing and Synthesis of New Fluorine Substituted Pyrimidine-Thion-5-Carbonitriles and the Related Derivatives as Photochemical Probe Agents for Inhibition of Vitiligo Disease

  AUTHORS: Mohammed S. T. Makki, Dina A. Bakhotmah, Reda M. Abdel-Rahman, Mohammed S. El-Shahawy

  KEYWORDS: Synthesis; Fluoropyrimidines; Photochemical Probes

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.2 No.3A, November 30, 2012

  ABSTRACT: A new biocidal agents fluorine substituted-3-thioxopyrimidine-5-carbonitriles (2-9) and/or the related fluorine substi- tuted pyrimido (4,5-d) pyrimidines (10-14) were synthesized by the cycloaddition of fluorinated β- arylidine malo- nonitriles (1a-c) followed by a nucleophilic attack against α,β-bifunctional reagents in different conditions. Structures of the fluorine targets were characterized by their elemental analysis and spectral data (UV, IR, 1H NMR, 13C NMR and mass measurements) and further evaluated as photochemical probe for inhibition of Vitiligo, it was found that compounds 5, 9, 11 and 12 exhibited high potency over the investigated compounds.