M. Gellet, K. Mizuuchi, M. H. O’Dea and H. A. Nash, “DNA Gyrase: An Enzyme That Introduces Superhelical Turns into DNA,” Proceedings of the National Academy of Sciences USA, Vol. 73, No. 11, 1976, pp. 3872-3878.

has been cited by the following article:

• TITLE: The Synthesis, Characterization and Application of Ciprofloxacin Complexes and Its Coordination with Copper, Manganese and Zirconium Ions

  AUTHORS: Zhengde Tan, Fengjiao Tan, Li Zhao, Junyong Li

  KEYWORDS: Ciprofloxacin; Ligand; Characterization; Antibacterial

  JOURNAL NAME: Journal of Crystallization Process and Technology, Vol.2 No.2, April 24, 2012

  ABSTRACT: In our work, ciprofloxacin was extracted from the raw material ciprofloxacin hydrochloride and coordinated with the metal ions of copper, manganese and zirconium. The procedures include the comparison of the autoclave method with the solvothermal method, synthesizing the corresponding complexes and conducting antibacterial test on nearly 20 kinds of bacteria. It is shown that under the condition of PH1 and 110℃ - 116℃, the autoclave method and solvothermal method can be utilized to obtain the ciprofloxacin complexes with Cu2+, Mn2+ and Zr2+ as the metal ligands after reacting for 8 hours. The raw material, ligands and monocrystals were characterized by IR, DSC, UV and fluorescence spectrum. Meanwhile a great number of antibacterial tests were carried out, revealing favorable bacteriocidal properties of the resulting complexes.