National Academy of Sciences, National Research Council, Life Sciences Council, “The Health effect of Nitrate, Nitrite and N-Nitroso,” National Academy Press, Washington DC, 1981.

has been cited by the following article:

• TITLE: Role of Nitrite in Tumor Growth, Symbiogenetic Evolution of Cancer Cells, and China’s Successes in the War against Cancer

  AUTHORS: Kenneth J. Hsu, Chao S. Huangfu, Min Z. Qin

  KEYWORDS: Nitrite, Tomor, Symbiogenetic Evolution

  JOURNAL NAME: Journal of Cancer Therapy, Vol.2 No.5, December 31, 2011

  ABSTRACT: Statistics and experiments indicate a correlation between cancer mortality and nitrite in drinking water. Nitrite is a reductant that can deprive a cell of oxygen; it is also an oxidant that can be a substrate in anaerobic ammonium oxidation, the metabolic mode of the anammox bacteria. Eukaryote cells evolved through a fusion of anaerobic and aerobic bacteria. We postulate that an anammox bacterium sought refuge in a fusion with a membrane-bound cluster of aerobic bacteria. While the latter evolved into mitochondria organelles, the former became the nucleus of a prokaryote cell. Eventually, oxidative phosphorilation is the characteristic metabolic pathway of normal eukaryote cells, and we postulate that anammox is the protein-catabolism pathway for cancer cells. The metabolism consumes nitrite and explains thus the link between nitrite and cancer.