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J. S. Park, T. H. Han, K. Y. Lee, S. S. Han, J. J. Hwang, D. H. Moon, S. Y. Kim and Y. W. Cho, “N-Acetyl Histidine-Conjugated Glycol Chitosan SElf-Assembled Nanoparticles for Intracytoplasmic Delivery of drugs: Endocytosis, Exocytosis and Drug Release,” Journal of Controlled Release, Vol. 115, No. 1, 2006, pp. 37-45.
doi:10.1016/j.jconrel.2006.07.011
has been cited by the following article:
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TITLE:
Reducible Poly (2-Dimethylaminoethyl) Methacrylate-Block-Polyvinylimidazole: Synthesis, Transfection Activity in Vitro
AUTHORS:
Bozhang Yu
KEYWORDS:
Reducible Polymer; Gene Expression; Transfection; Cytotoxicity
JOURNAL NAME:
Journal of Biomaterials and Nanobiotechnology,
Vol.3 No.1,
January
12,
2012
ABSTRACT: Reducible or imidazolyl polycations of block poly(imidazole/2-dimethyl aminoethyl) are of promising in gene delivery. Dimeric poly(2-dimethyl aminoethyl) methacrylate-block-polyvinylimidazole (rDPDMAEMAIM) and reducible poly (2-dimethylaminoethyl) methacrylate (rDPDMAEMA) with single disulfide bond in the backbone was synthesized by oxidizing their dithioester-terminated polymers. The polyplexes sizes, rDPDMAEMAIM/pDNA and rDPDMAEMA/ pDNA (plasmid DNA) are in the ranges of 100 nm - 150 nm at the weight ratio of 12:1, and the zeta potential of rDPDMAEMAIM/pDNA from 9.6 mV to 22.7 mV in PBS solutions increases with their weight ratios of 1:1 to 18:1. The results show that the rDPDMAEMAIM/pDNA polyplexes have higher transfection activity and lower cytotoxicity than that of rDPDMAEMAIM/pDNA against 293T cells in vitro in the presence of serum, indicating that the PDMAEMAIM present a promising nonviral gene vector.