Barnard, D.A., Irusen, E.M., Bruwer, J.W., Plekker, D., Whitelaw, A.C., Jacobus, D., Deetlefs, J.D., et al. (2015) The Utility of Xpert MTB/RIF Performed on Bronchial Washings Obtained in Patients with Suspected Pulmonary Tuberculosis in a High Prevalence Setting. BMC Pulmonary Medicine, 15, Article No. 103.
https://doi.org/10.1186/s12890-015-0086-z

has been cited by the following article:

• TITLE: Missed Opportunities for Diagnosing Bacilliferous Pulmonary Tuberculosis by Optical Microscopy versus GeneXpert MTB/RIF in Endemic Areas

  AUTHORS: Aba Yapo Thomas, Nassoué Dobré Olivia, Yéo Liomehin, Monemo Pacome, Yapo Matine Tatiana, Achi Hoboueu Vincent

  KEYWORDS: Bacilliferous Pulmonary Tuberculosis, Missed Opportunity, GeneXpert MTB/RIF, Optical Microscopy

  JOURNAL NAME: Advances in Infectious Diseases, Vol.13 No.4, December 25, 2023

  ABSTRACT: Objective: To assess the missed opportunities from the diagnosis of bacilliferous pulmonary tuberculosis by optical microscopy compared to GeneXpert MTB/RIF between 2015 and 2019. Methods: This is a retrospective analysis of the diagnostic results of bacilliferous pulmonary tuberculosis in patients suspected of pulmonary tuberculosis at their first episode during the period. GeneXpert MTB/RIF (GeneXpert) and optical microscopy (OM) after Ziehl-Neelsen stained smear were performed on each patient’s sputum or gastric tubing fluid sample. Results: Among 341 patients suspected of pulmonary tuberculosis, 229 patients were declared bacilliferous tuberculosis by the two tests (67%), 220 patients by GeneXpert and 95 patients by OM, i.e. 64.5% versus 28% (p i.e. 58.5% of the positive cases detected by the two tests (134/229 patients) and 39.3% of the patients suspected of tuberculosis (134/341 patients). On the other hand, among 95 patients declared positive by OM, the GeneXpert ignored 9 (9.5%), i.e. 4% of all the positive cases detected by the two diagnostic tests (9/229 patients) and 3% of the patients suspected of tuberculosis (9/341 patients). The differences observed between the results of the two tests were statistically significant at the 5% threshold (p Conclusion: This study reveals missed diagnostic opportunities for bacilliferous pulmonary mycobacteriosis, statistically significant with optical microscopy than GeneXpert. The GeneXpert/optical microscopy couple could be a good contribution to the strategies for the elimination of pulmonary tuberculosis in sub-Saharan Africa.