TITLE:
Association between Neutrophil-Lymphocyte Ratio (NLR) and Clinical Outcomes among Filipino Patients with End-Stage Renal Disease (ESRD) Secondary to Diabetic Nephropathy on Maintenance Hemodialysis
AUTHORS:
Lovenia Anne Olores, Grecia Darunday, Eratosthenes Polito, Ruben Maguad
KEYWORDS:
Neutrophil-Lymphocyte Ratio, Diabetic Nephropathy, Maintenance Hemodialysis, Filipino, ESRD
JOURNAL NAME:
Open Access Library Journal,
Vol.10 No.9,
September
7,
2023
ABSTRACT: The incidence of end-stage renal disease (ESRD) is increasing in the Philippines. The presence of diabetes mellitus further worsens ESRD prognosis. The neutrophil-to-lymphocyte ratio (NLR) is a reliable prognostic marker for mortality, but its usefulness as a prognostic biomarker in diabetes patients with chronic kidney disease is yet to be clarified. This study aimed to determine the association between NLR and morbidity among Filipino patients with end-stage renal disease (ESRD) secondary to diabetic nephropathy on maintenance hemodialysis. This was an observational descriptive, prospective cohort study that evaluated outpatient Filipino citizens aged > 18 years diagnosed with ESRD secondary to type 2 diabetes mellitus (T2DM). All patients had good compliance with their hemodialysis regimen (i.e., at least twice weekly dialysis within the past 3 months). The patients were divided into two groups according to the baseline NLR value at a cut-off of 3.5 as the high NLR group (≥3.5) and the low NLR group (