Article citationsMore>>
Garces, S., Khoury, J.D., Kanagal-Shamanna, R., Salem, A., Wang, S.A., Ok, C.Y., Hu, S., Patel, K.P., Routbort, M.J., Luthra, R., Tang, G., Schlette, E.J., Bueso-Ramos, C.E., Medeiros, L.J. and Loghavi, S. (2018) Chronic Lymphocytic Leukemia with Proliferation Centers in Bone Marrow Is Associated with Younger Age at Initial Presentation, Complex Karyotype, and TP53 Disruption. Human Pathology, 82, 215-231.
https://doi.org/10.1016/j.humpath.2018.07.030
has been cited by the following article:
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TITLE:
A Rare Entity of Accelerated Chronic Lymphocytic Leukemia: A Report of Two Cases and Review of Literature
AUTHORS:
Zahra Kmira, Ben Yahya Noura, Chembah Wafa, Ben Sayed Nesrine, Chiba Dorra, Bouteraa Walid, Zaier Monia, Ben Youssef Yosra, Haifa Regaieg, Khelif Abderrahim
KEYWORDS:
Accelerated Chronic Lymphocytic Leukemia, Richter Transformation, Prognosis, Treatment
JOURNAL NAME:
Health,
Vol.15 No.8,
August
22,
2023
ABSTRACT: Background: Accelerated-chronic lymphocytic leukemia (A-CLL) is a rare disease entity as it represents less than 1% of all reported cases of chronic lymphoid leukemia (CLL). Moreover, it is most likely an under diagnosed entity due to its rarity and the non-standardized practice of lymph node biopsy in CLL. Purpose: The aims of our work are to establish the diagnosis of A-CLL and to study the prognosis and treatment of this rare entity. Method: here, we report the clinical presentation and the follow up of two cases of A-CLL. Results: Distinguishing Richter transformation (RT) from A-CLL is important as it may result in a major change in disease management. The prognosis of A-CLL is intermediate between CLL and RT. The prognosis is mainly poor due to a predominance of poor prognostic markers including an increasing number of p53-positive cases. Conclusion: To this date, no prospective study has been led to define the best treatment for A-CLL. The shorter survival of A-CLL when compared to typical CLL implies the need of a more aggressive treatment.
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