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has been cited by the following article:

• TITLE: Late Onset Combined Immune Deficiency (LOCID) Revealed by a Haemolytic Anaemia in a Child: A Case Report

  AUTHORS: Amal Hamami, Maria Rkain, Madiha Benhachem, Ayyad Ghannam, Aziza Elouali, Abdeladim Babakhoua, Noufissa Benajiba

  KEYWORDS: Haemolytic Anaemia, LOCID, Immune Deficiency, Child

  JOURNAL NAME: Open Journal of Pediatrics, Vol.13 No.3, May 15, 2023

  ABSTRACT: Variable Common Immune Deficiency (VCID) is a very heterogeneous condition both clinically and immunologically. It is a group of molecular abnormalities responsible for a defect in antibody production leading to hypogammaglobulinemia often associated with autoimmune and/or lymphoproliferative manifestations. Late Onset Combined Immune Deficiency (LOCID) is a type of Variable Common Immune Deficiency (VCID) defined by a defect in antibody production (IgG and IgA ± IgM type), profound CD4 T-cell lymphopenia and frequent opportunistic infections. LOCID has been considered as a distinct entity from VCID due to its particular clinical and immunological profile.