Zacharias, H.U., Weihs, A., Habes, M., Wittfeld, K., Frenzel, S., Rashid, T., Stubbe, B., Obst, A., Szentkiralyi, A., Bulow, R., Berger, K.K, Fietze, I., Penzel, T., Hosten, N., Ewert, R., Volzke, H. and Grabe, H.J. (2021) Association between Obstructive Sleep Apnea and Brain White Matter Hyperintensities in a Population-Based Cohort in Germany. JAMA Network Open, 4, e2128225.
https://doi.org/10.1001/jamanetworkopen.2021.28225

has been cited by the following article:

• TITLE: Mathematical Model for Stroke and White Matter Hyperintensities

  AUTHORS: James M. Gregory

  KEYWORDS: Stroke, White Matter Hyperintensities, WMH, Aging, Depression, Trauma, PTSD

  JOURNAL NAME: Journal of Behavioral and Brain Science, Vol.13 No.4, April 30, 2023

  ABSTRACT: A mathematical model was developed to predict the risk of having a stroke as a person ages. The age component was derived from the concept that the change in risk of stroke with age is a function of the current risk of developing a stroke. This equation modeled the trend with age reported in the literature for two different data sets with R2 values of 0.97 or better for both men and women. A second equation of a similar nature was developed to predict the accumulation of white matter hyperintensities, WMH, as a person ages. It appears that each equation includes a set of common risk factors. This set of common risk factors allows an individual’s risk for stroke to be based on measured WMH. A third equation links WMH with the risk of developing a stroke. This equation allows an individual to use measured WMH from brain scans to predict the future risk of developing a stroke. In theory, a person with a relatively high measurement of WMH can project future risk for stroke with age and use counter measures such as exercise and medications to keep other risk factors low as a person continues to age.