TITLE:
Thrombotic Events in Patients with Antiphospholipid Syndrome: A Single Center Study
AUTHORS:
H. Khachatryan, L. Sahakyan, G. Sargsyan, S. Danelyan, I. Karapetyan, S. Petrosyan, N. Ghukasyan, A. Stepanyan, A. Poghosyan, A. Harutyunyan, K. Ginosyan, K. Arustamyan, G. Tamamyan, N. Sargsyan
KEYWORDS:
Thrombotic Complications, Thrombophilia, Antiphospholipid Syndrome
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.13 No.3,
March
31,
2023
ABSTRACT: Background: There is
limited literature regarding risk factors for development of thrombosis and
long-term thrombotic outcomes in Armenian APS patients. The aim of the study is
to identify patients with APS with thrombotic complications and to evaluate the
epidemiological statistics of thrombosis and thrombophilia and their
complications in Armenia. Methods: We analyzed medical records of
Patients with APS from January 2018 to December 2021 treated at the Armenian Thrombosis and Hemostasis Center was enrolled. Results: Both acquired and hereditary thrombophilia increase
the risk of thrombosis. Thrombophilia was present in 61.5% of 123 patients. It
was found that 38 pregnant women with thrombosis had a family history of VTE,
myocardial infarction or stroke in the next of kin under 50 years of age. The
prevalence of this history was 31.4% (11 patients) compared to 68.6% (27
patients), who did not have 41.6% of postpartum thrombotic events up to two
months postpartum. Conclusion: Thrombosis in pregnancy is a redoubtable
complication requiring an excellent cooperation between the obstetrician and
hematologist. Clear detection of thrombosis in APS patients in all types allows
to accurately predicting the method and duration of anticoagulant treatment and
to prevent thrombotic complications.