Zheng, Y.-M., Chen, X.-Y., Cai, J.-Y., et al. (2021) Washed Microbiota Transplantation Reduces Proton Pump Inhibitor Dependency in Nonerosive Reflux Disease. World Journal of Gastroenterology, 27, 513-522.
https://doi.org/10.3748/wjg.v27.i6.513

has been cited by the following article:

• TITLE: Rifaximin in the Treatment of Gastroesophageal Reflux Disease: A New Idea Based on the Relationship between Intestinal Microecology and Gastroesophageal Reflux Disease

  AUTHORS: Di Yang, Guangyang Zheng, Peilong Wang, Lei Huang

  KEYWORDS: Gastroesophageal Reflux Disease, Intestinal Microecology, Rifaximin

  JOURNAL NAME: International Journal of Clinical Medicine, Vol.14 No.3, March 29, 2023

  ABSTRACT: Rifaximin in the Treatment of Gastroesophageal Reflux Disease (GERD) is a common clinical disorder, the most common symptom of which is a burning sensation behind the breastbone (heartburn) or reflux of stomach contents into the upper pharynx (acid reflux). The prevalence in China is increasing year by year, which can affect the quality of life of patients and also increase the economic burden on families and society. The pathogenesis of GERD is still unclear, and some studies suggest that intestinal microecology may be closely related to the development of GERD. Rifaximin is not readily absorbed orally and acts locally in the intestine, so it has mild adverse effects and good safety, and can be used to treat gastrointestinal diseases such as irritable bowel syndrome, traveler’s diarrhea, small intestinal bacterial overgrowth, diverticulosis, inflammatory bowel disease and hepatic encephalopathy. Therefore, this paper focuses on intestinal microecology as a possible pathogenesis of GERD and further explores the feasibility of rifaximin for the treatment of GERD.