TITLE:
Investigation into the Intake of Edible Mushroom Pleurotus ostreatus (Aqueous Extract Oyster Mushroom) on Biochemical Indices of Female Wistar Rats
AUTHORS:
Edson Henrique Pereira de Arruda, Marise Auxiliadora de Barro Reis, Leonardo Marin, Lavinia Almeida Muller, Amilcar Sabino Damazo, Marli Gerenutti, Márcia Queiroz Latorraca, Ceci Sales-Campos
KEYWORDS:
Edible Mushroom, Nutraceuticals, Pleurotus ostreatus, Aqueous Extract Oyster Mushroom, Biochemical Analyzes
JOURNAL NAME:
American Journal of Plant Sciences,
Vol.14 No.2,
February
27,
2023
ABSTRACT: Pleurotus
ostreatus, popularly known as oyster mushroom, has
nutraceutical properties that include hypocholesterolemic, hypoglycemic,
antioxidant, anti-inflammatory, antitumor, hepatoprotective and hypotensive
activities. Aqueous Extract Oyster Mushroom (AEOM) containing lyophilized P. ostreatus reconstituted in 0.9%
saline solution was evaluated for its effect on body weight, biochemical
indices and pancreas morphometry. Twelve healthy Wistar female rats were
assigned to Control and AEOM groups, consisting of rats that received 0.9%
saline solution and AEOM (100 mg/kg/day), respectively, administered by oral
gavage at 3 mL/kg of body weight for 15 days. The animals had free access to
commercial feed and water ad libitum.
Blood was obtained by cardiac puncture and serum was used to biochemical determinations.
Pancreas was excised, weighed and fixed in 4% neutral buffered formalin
for histopathological examination. Initial and final body weights, and absolute and relative weights of
pancreas did not differ between the groups. Total cholesterol, HDL-c, albumin
and uric acid were lower in the AEOM group compared to the control group. The
serum concentration of total proteins, glucose, triglycerides, alanine
aminotransferase, aspartate aminotransferase, alkaline phosphatase, lactate
dehydrogenase, creatinine and urea were similar in the groups. Pancreas of rats
treated with AEOM exhibited an increase in the size of pancreatic islet. Thus,
the use of AEOM is relatively safe at the dose studied and produces hypertrophy
of the pancreatic islets without altering glycemic homeostasis.