TITLE:
Abnormalities of Serum Protein Fractions in Hemodialysis Patients with Chronic Renal Failure at Ouagadougou, Burkina Faso
AUTHORS:
Arnaud Kouraogo, Fabienne Soudre, Alice Kiba, Raoul Karfo, Ollo Da, Emmanuel Zongo, Elie Kabre, Jean Sakande
KEYWORDS:
Protein Fractions, Albumin, Globulin, Hemodialysis
JOURNAL NAME:
Advances in Biological Chemistry,
Vol.12 No.6,
December
9,
2022
ABSTRACT: Introduction: The main objective of this study was to investigate abnormalities of serum protein fractions in hemodialysis patients with chronic renal failure (CRF) in Ouagadougou, Burkina Faso. Methods: This was a descriptive cross-sectional study of 48 hemodialysis patients with chronic renal failure (CRF) recruited at the Yalgado Ouedraogo Teaching Hospital (YO-TH), and 48 controls declared fit to donate blood by the Regional Blood Transfusion Center (RBTC) of Ouagadougou. Urea, creatinine, uric acid, and serum proteins were measured on the ARCHITECT C4000 equipment (ABOTT®), while the separating of the different protein fractions was performed on the Helena SAS 3 & 4 automated system. Results: A total of 96 individuals were included in the study. Protein levels were on average higher in controls (75.19 ± 6.56 g/L) than in hemodialysis patients (71.44 ± 12.33 g/L). Low blood albumin was significantly associated with the CRF hemodialysis groups compared to controls (p Conclusion: Serum protein electrophoresis is rapidly feasible and low cost. In hemodialysis CKD patients, it can be used to guide therapeutic management and predict morbidity and mortality related to variations in the various protein fractions.