TITLE:
Efficacy and Safety of 30% Supramolecular Salicylic Acid Peeling Combined with Isotretinoin Erythromycin Gel in the Treatment of Moderate-to-Severe Acne Vulgaris: A Comparative Study
AUTHORS:
Jie Chen, Yusha Guo, Ying Wu, Xiaoqin Zhao, Jing Yang
KEYWORDS:
30% Supramolecular Salicylic Acid, Isotretinoin Erythromycin Gel, Moderate-to-Severe Acne Vulgaris, Efficacy, The Adverse Reactions, Recurrence Rate
JOURNAL NAME:
International Journal of Clinical Medicine,
Vol.13 No.10,
October
24,
2022
ABSTRACT: Background: Both 30% supramolecular salicylic acid (SA) and isotretinoin erythromycin gel (IEG) have proven efficacy with good safety profiles in the treatment of acne vulgaris. Objectives: This study compared the clinical efficacy and safety of 30% SA peeling and IEG in the treatment of moderate-to-severe acne vulgaris. Methods: Patients with moderate-to-severe acne vulgaris were randomized into 3 groups of 30 persons each, and treated with SA peel, or IEG, or SA combine with IEG (SA + IEG group). Evaluation of acne was done by effective rate and individual lesion counts. And the adverse effects and recurrence were recorded. Results: The SA + IEG group was better in clinical efficacy and treating noninflammatory and inflammatory lesions than that of single treatment group (P 0.05). Conclusion: 30% SA combined with IEG had a significant effect in the treatment of moderate-to-severe acne lesions.