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has been cited by the following article:

• TITLE: NLR’s Analogs with Young Blood Cells in Monitoring of Toxicity of Long-Term Preventing Immunosuppression in the Liver Transplant’s Recipients

  AUTHORS: Aleksey N. Shoutko, Olga A. Gerasimova

  KEYWORDS: Liver, Transplantation, Health, Late Period, Monitoring, Stem, Progenitor Cells, NLR

  JOURNAL NAME: Open Journal of Biophysics, Vol.12 No.4, September 30, 2022

  ABSTRACT: The blood neutrophils to lymphocytes ratio (NLR) reflects the physiological homeostasis between lymphopoiesis and myelopoiesis, and its elevation serves as a harmful sign in many pathologies, partially, late rejection of allograft. The stem and young lymphoid cells have regenerative-trophic properties, which can affect the relevance of NLR, being opposed to immune properties, associated with bulk lymphocytes. In the present article, we have analyzed for the first time the applicability of NLR’s analogs with stem and immature blood cells for monitoring harmful long-term shifting from lymphopoiesis to myelopoiesis in transplant’s recipients received conventional immunosuppressive treatment. In opposition to conventional NLR, the ratio of subpopulation of CD31 cells committed to the liver tissue by alfa-fetoprotein (AFP), seems sensitive enough for such monitoring several years after transplantation of the liver from the dead.