TITLE:
Based on PK/PD and Monte Carlo Simulation Analysis of the Dosing Regimens of Micafungin in Children with Febrile Neutropenic
AUTHORS:
Jiuli Hu, Ying Wang, Junhui Hu, Xiaolei Yu, Xiaoqin Zhu
KEYWORDS:
PK/PD Model, Mote Carlo Simulation, Micafungin, Febrile Neutropenic
JOURNAL NAME:
Open Journal of Pediatrics,
Vol.12 No.4,
September
26,
2022
ABSTRACT: Neutropenia with fever is a special group of patients. Due to low immune function, inflammation-related clinical symptoms and signs are often not
obvious, and pathogenic bacteria and infection focus are not clear. Fever may
be the only sign of infection. If appropriate antimicrobial treatment is not
given in time, infection-related mortality is high. In our study, we aimed to
optimize the dosage regimen of Micafungin in
children with febrile neutropenic against Candida spp. by Mote Carlo Simulation (MCS). Pharmacokinetic parameters and microbiological data of Micafungin
were collected. Then we used MCS to calculate Probability of Target
Attainment (PTA) and Cumulative Fraction of Response
(CFR). With dosages of 0.5 mg/kg, 1 mg/kg, 1.5 mg/kg, 2 mg/kg, 3 mg/kg,
and 4 mg/kg in oral group and dosages of 100 mg, and 200 mg in intravenous administration, all have different degree of antifungal
effect. But when the dosage regimen was 50 mg IV, the therapeutic effect of Micafungin against Candida spp. was not good.