TITLE:
Synthesis, Photophysical Properties and DNA-Photocleavage Activity of Silicon Phthalocyanine Derivatives
AUTHORS:
Kunhui Sun, Yanli Ge, Jun Yang, Xuelei Hu
KEYWORDS:
Silicon Phthalocyanine, Fluorescence Quantum Yield, Singlet Oxygen Quantum Yield, DNA-Photocleavage Activity
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.13 No.6,
June
30,
2022
ABSTRACT: Silicon phthalocyanine derivatives 1a and 1b were
synthesized and characterized by UV, 1H-NMR and MS. The
photophysical properties of the compounds in DMSO were investigated. The
maximum absorption peaks of compounds 1a and 1b at the Q-band are 681 nm. With ZnPc (ΦF = 0.20, ΦΔ = 0.67) as a reference, the
fluorescence quantum yield (ΦF)
of 1a and 1b are 0.20 and 0.31 respectively, and the singlet oxygen quantum
yield (ΦΔ) are 0.66 and 0.59 respectively. The DNA-photocleavage
activities of compounds 1a and 1b were studied by gel electrophoresis.
Compounds 1a and 1b possess good photocleavage activity to pBR322 DNA. The
results demonstrate that compounds 1a and 1b are potential photosensitizers for
tumor therapy.