Brinker, M.R., Timberlake, G.A., Goff, J.M., Rice, J.C. and Kerstein, M.D. (1988) Below-Knee Physiologic Cryoanesthesia in the Critically Ill Patient. Journal of Vascular Surgery, 7, 433-438.
https://doi.org/10.1016/0741-5214(88)90441-7

has been cited by the following article:

• TITLE: Is the Critical Patient with a Septic Limb Too Sick for an Emergent Amputation? A Case Report Illustrating How to Perform a Bedside Physiologic Amputation

  AUTHORS: Samantha A. Delapena, Luis G. Fernandez, Devin O’Connor, Katharine A. Dishner, Marc R. Matthews

  KEYWORDS: Physiologic Amputation, Cryoamputation, Critically Ill, Sepsis, Septic Shock, Cryoanesthesia Amputation, Medical Amputation

  JOURNAL NAME: Surgical Science, Vol.13 No.4, April 28, 2022

  ABSTRACT: A physiologic amputation is an important option for the critically ill patient who has irreversible limb disease with necrotic wounds but who would have a low probability of surviving a standard open amputation, without effective preoperative resuscitation, antibiotics, and correction of metabolic derangements. An open amputation may be required secondary to vascular ischemic disease, necrotizing fasciitis, or thermal injury that has led to the critical and unstable condition. The physiologic amputation stabilizes the patient while preventing further metabolic deterioration. The cryoamputation is intended to rescue the patient’s life and is not meant for limb salvage. While physiologic amputation has been described for over a century, it is uncommonly performed. This case report describes a physiologic amputation in a step-by-step fashion for the surgeon attempting to save a critically ill patient’s life who might not otherwise survive an open amputation.