TITLE:
SARS-COV-2 Induce Pulmonary Injury from Basic to Clinical Research
AUTHORS:
Jinguo Zhu
KEYWORDS:
COVID-19, SARS-CoV-2, Pulmonary Injury, Clinical Manifestation, Treatment Strategies
JOURNAL NAME:
World Journal of Cardiovascular Diseases,
Vol.12 No.3,
March
31,
2022
ABSTRACT: The SARS-CoV-2 has infected over 194,909,000 cases and over 4,170,000 deaths in the world before the end of July 2021. The virus attacks human alveoli and induces severe lung injury (COVID-19 disease) and spreads rapidly. The mechanisms of COVID-19 disease are unclear. To better understand this disease, This review analyzes the SARS-CoV-2 biological characteristics, insights the effect of alveolar epithelium and its adjacent microvascular endothelium, investigates human host cells immune response and immunothrombosis. Explains clinical manifestations of COVID-19 associated lung injury. It may be helpful for development management strategies for COVID-19 associated pulmonary damage.