Kleinschmidt, I., Bradley, J., Knox, T.B., Mnzava, A.P., Kafy, H.T., Mbogo, C., Ismail, B.A., Bigoga, J.D., Alioun Adechoubou, A., Raghavendra, K., Cook, J., Malik, E.M., Nkuni, Z.J., Macdonald, M., Bayoh, N., Ochomo, E., Fondjo, E., Awono-Ambene, H.P., Etang, J., Akogbeto, M., Bhatt, R.M., Chourasia, M.K., Swain, D.K., Kinyari, T., Subramaniam, K., Massougbodji, A., Okê-Sopoh, M., Ogouyemi-Hounto, A., Kouambeng, C., Abdin, M.S., West, P., Elmardi, K., Cornelie, S., Corbel, V., Valecha, N., Mathenge, E., Kamau, L., Lines, J. and Donnelly, M.J. (2018) Implications of Insecticide Resistance for Malaria Vector Control with Long-Lasting Insecticidal Nets: A WHO-Coordinated, Prospective, International, Observational Cohort Study. The Lancet Infectious Disease, 18, 640-649.
https://doi.org/10.1016/S1473-3099(18)30172-5

has been cited by the following article:

• TITLE: Evaluation at the Level of Health Facilities, of the Protective Efficacy of LLINs in Children under 5 Years Old from Localities of Low and High Resistance of Vectors to Pyrethroid Insecticides in Benin in West Africa

  AUTHORS: Tokponnon Tatchémè Filémon, Ossè Razaki, Arthur Sovi, Wakpo Abel, Hounto Ogouyémi Aurore, Sissinto Yolande, Adechoubou Alioun, Houansou Télesphore, Oke Mariam, Kinde-Gazard Dorothée, Massougbodji Achille, Akogbeto Martin

  KEYWORDS: Case-Controls, LLINs, Malaria Morbidity, Pyrethroids Resistance, Benin

  JOURNAL NAME: Advances in Infectious Diseases, Vol.12 No.1, March 2, 2022

  ABSTRACT: Context: The resistance to pyrethroids in malaria vectors continues to grow in Africa and could therefore compromise or reduce substantially the effectiveness of LLINs in preventing malaria. It is therefore of paramount importance to evaluate the protective efficacy of LLINs in children sleeping in areas of vector resistance to insecticides in order to draw lessons for future interventions. This study assesses the effect of the use of LLINs on malaria morbidity in clusters of low and high resistance of vectors to pyrethroids. Methods: This is a cross-sectional case-control study with one control for one case that was conducted in the communes of Kétou, Ifangni, Kétou, and Pobè in the Plateau department of southern Benin. The use of LLINs and malaria morbidity was measured and compared in children from clusters of low and high vector resistance to insecticides. In each commune, 30 cases and 30 controls were recruited for a total of 240 children under 5 years of age from villages with low and high insecticide resistance. Results: According to the localities of origin of the children, of all parents of children surveyed, 169 (70.4%) asserted the children slept under an LLIN the day before they arrived at the health center. This rate represents 70.8% (85 children) among the cases and 70.0% (84 children) among the controls without significant difference (p = 0.8). The use of LLINs the day before the survey, the frequency of their use during the two weeks preceding the day of the survey, their availability at the household level, the use of other tools for protection against mosquito bites are the same in the two groups of children (cases and controls) (p > 0.05) as well in low and high resistance villages. On the other hand, the parasite prevalence, the splenomegaly and the geometric means of the parasite densities, are significantly higher in the cases than in the controls (p Conclusion: The evaluation of epidemiological indicators in children under five years old at the level of health centers did not enable demonstrating the impact of resistance on the operational effectiveness of the LLINs. The information collected within the four health facilities only reflects the situation that should normally be seen in the population under the real conditions of use of LLINs in high and low resistance areas.