Tan, L., Yang, H.P., Pang, W., Lu, H., Hu, Y.D., Li, J., Lu, S.J., Zhang, W.Q. and Jiang, Y.G. (2014) Cyanidin-3-O-Galactoside and Blueberry Extracts Supplementation Improves Spatial Memory and Regulates Hippocampal ERK Expression in Senescence-Accelerated Mice. Biomedical and Environmental Sciences, 27, 186-196.
https://doi.org/10.3967/bes2014.007

has been cited by the following article:

• TITLE: Induction of Sirtuin1 Activity in SH-SY5Y Cells by Cyanidin-3-O-Glucocide Induced

  AUTHORS: Kaori Yama, Yoshiki Hasebe, Ayuka Inomata, Jun Miura, Ainari Konda

  KEYWORDS: Cyanidin-3-O-Glucocide, Sirtuin1, Anti-Senescence, Antioxidant, Oxidative Stress, Nerve Cells

  JOURNAL NAME: Pharmacology & Pharmacy, Vol.13 No.2, February 11, 2022

  ABSTRACT: An increase in oxidative stress plays a key role in neurotoxicity induction and cell death, which leads to neurodegenerative diseases such as Parkinson’s disease and Alzheimer’s disease. Cyanidin-3-glucoside (C3G) is a common anthocyanin and shows antioxidant activity in neuronal cells. Silent information regulator 2-related protein 1 (Sirt1) regulates antioxidant and anti-inflammatory effects. However, the effects of C3G on Sirt1 in neuronal cells remain unclear. This study evaluated the effect of C3G on Sirt1 expression and activity in human neuroblastoma (SH-SY5Y) cells. In the study, C3G increased the expression of Sirt1 and Sirt1 activity in SH-SY5Y cells. Additionally, C3G increased the expression of nuclear factor erythroid 2-related factor 2, a vital transcription factor for regulating the expression of antioxidant genes, as well as antioxidant enzymes such as superoxide dismutase and catalase. Moreover, C3G protected SH-SY5Y cells from oxidative stress. These results suggest that C3G decreased oxidative stress-induced cell injury by increasing the expression of Sirt1 and other antioxidant factors. Therefore, C3G might merit further investigation for use in attenuating the progress of neurodegenerative diseases.