TITLE:
Association between Arg16Gly Polymorphism in the Β2-Adrenergic Receptor Gene and Obesity Risk in Patients with Bronchial Asthma
AUTHORS:
Vladyslava V. Kachkovska, Viktor F. Orlovskyi
KEYWORDS:
Bronchial Asthma, Onset, Obesity, Arg16Gly Polymorphism in the β2-Adrenoceptor Gene
JOURNAL NAME:
Open Journal of Genetics,
Vol.11 No.4,
November
25,
2021
ABSTRACT: The objective of our study was to investigate
the association between the Arg16Gly polymorphism in the β2-АR gene and body mass index (BMI) in patients with
bronchial asthma (BA) with regard to the age of onset. Materials and methods: 553 patients were examined. The control group consisted of 95 apparently
healthy individuals. The patients were divided into 2 groups depending on the
age of BA onset: 282 patients with late onset (Group I) and 271 patients with
early onset (Group II). Arg16Gly polymorphism in the β2-АR
gene (rs1042713) was determined using polymerase chain reaction- restriction fragment length
polymorphism analysis. Statistical analysis of obtained results was performed
using SPSS–17 program. Results: There was no significant
difference in the distribution of genotypes for Arg16Gly polymorphism in the β2-AR gene depending on BMI (χ2 = 5.74; р = 0.22), and no
association was found with obesity risks disregarding the age of BA onset. The
study on the frequency of genotypes for this polymorphism with regard to the
age of asthma onset and BMI found statistically significant differences between
early-onset (χ2 = 11.27; p
= 0.02) and late-onset (χ2 = 10.66; p = 0.03) asthma. It was found that the risk of obesity in Group I
patients was 1.57 times higher in the additive model and 2.67 times higher—in
the recessive model of inheritance. In patients with late-onset asthma, Gly16
allele in the recessive model of inheritance was found to have a protective
role against obesity. Conclusions: There was no
significant difference in the distribution of genotypes for Arg16Gly
polymorphism in the β2-AR
gene with regard to BMI, and no association was found with obesity risks in BA
patients disregarding the age of BA onset. The risk of obesity in patients with
early-onset asthma was 1.6 times higher in the additive model and 2.7 times
higher—in the recessive model of inheritance.