TITLE:
Syntheses, Characterization and Biological Activity of Novel Thiazoylazo Dye and Its Coordination Compounds
AUTHORS:
Temitayo O. Aiyelabola
KEYWORDS:
Coordination Compounds, 2-Amino-4, 5-Dimethylthiazole, 5-Methyl-2-(Propan-2-yl)phenol, Anti-Inflammation, Thiazolylazo Dye
JOURNAL NAME:
Advances in Biological Chemistry,
Vol.11 No.5,
September
27,
2021
ABSTRACT: The present work describes the synthesis of a novel heterocyclic azo dye
by general diazonization of
2-amino-4,5-dimethylthiazole followed by the diazo- coupling
of the resulting diazonium ion with 5-methyl-2-(propan-2-yl)phenol to obtain ligand L. This was
characterized using Fourier-transformed infrared and electronic
spectrophotometry. Ligand L was further coordinated with five metal ions, M:L, 1:2 [M = Cu(II), Mn(II), Zn(II), Ni(II) and Co(II)]. The coordination
compounds obtained were characterized by electronic, IR spectrophotometry,
magnetic susceptibility and percentage metal analyses. The results obtained suggested
that a thiazoylazo dye was obtained as ligand L. It was proposed that
two molecules of the solvent coordinated to the metal ion in addition with the
ligands to give an octahedral geometry for copper(II), manganese(II) and
nickel(II) complexes. On the other hand, square planar geometry was suggested for zinc(II) and cobalt(II) complexes. The anti-infla- mmatory
activity of the ligand and coordination compounds was evaluated using four in vitro-based
assays viz: xanthine oxidase and
lipoxygenase inhibition assay, membrane stability and protein denaturation
assay. The synthesized compounds generally exhibited good anti-inflammatory
activity in all the assays carried out.
However, the reference standards, in this instance, were more effective
in the case of xanthine oxidase, lipoxygenase and protein denaturation
inhibitory assays. For the membrane stability study, the coordination compounds and ligand L elicited
more potent anti-inflammatory activity than the standard drug.