TITLE:
Effect of Goal-Directed Fluid Therapy on Lung Function, Cognitive Function and Inflammatory Response in Patients Undergoing Radical Esophageal Cancer Surgery under One-Lung Ventilation
AUTHORS:
Jibo Zhao, Yuanli Li, Dengyun Xia, Xiaojia Sun, Yuan Zhang, Fulong Li, Jinliang Teng
KEYWORDS:
Goal-Directed Fluid Therapy, Radical Resection of Esophageal Cancer, Lung Function, Cognitive Function, Inflammatory Response
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.12 No.9,
September
8,
2021
ABSTRACT: Objective: To explore the effects of goal-directed fluid therapy (GDFT) on lung
function, cognitive function and inflammatory response in patients undergoing
radical esophageal cancer surgery under one-lung ventilation. Methods: Sixty-seven patients undergoing radical esophageal cancer surgery were divided
into GDFT group (GDFT
therapy) and control group (conventional
liquid therapy). The changes in patients’ pulmonary function, cognitive function and inflammatory response were
evaluated. Results: Both alveolar-arterial oxygen partial pressure
difference [P(A-a)O2]
and respiratory index (RI)
increased at one-lung ventilation for 30 minutes (T2) and decreased
at one-lung ventilation for 60 minutes (T3), and after surgery (T4) in the two groups, and
the GDFT group was lower than the control group (P 0.05);
theoxygenation index (OI) of the two groups decreased at T2, T3,
and T4 compared with that at T1 (before one-lung ventilation), and the GDFT group was higher than the control
group (P 0.05). At T4 and
T5, the tumor necrosis factor α (TNF-α), interleukin 6 (IL-6),
central nervous system specific protein (S100β), and neuron specific enolase (NSE) in the GDFT group were lower
compared to the control group (P 0.05),
while interleukin-10 (IL-10) was higher compared to the control group (P 0.05); the incidence of perioperative neurocognitive
disorder (PND) in the GDFT group was lower than that in the control group (P 0.05). Conclusion: GDFT can help prevent lung
injury during radical esophageal cancer surgery under one-lung ventilation,
reduce the body’s
inflammatory response, and reduce the incidence of perioperative cognitive
disorder to a certain extent.