Gu, W., Lin, J., Hou, Y.Y., Lin, N., et al. (2020) Effects of Low-Dose Aspirin on the Prevention of Preeclampsia and Pregnancy Outcomes: A Randomized Controlled Trial from Shanghai, China. European Journal of Obstetrics & Gynecology and Reproductive Biology, 248, 156-163.
https://doi.org/10.1016/j.ejogrb.2020.03.038

has been cited by the following article:

• TITLE: Effects of Aspirin on Pregnancy Outcome and Serum Endothelin-1 and Thrombomodulin Levels in Pregnancy Patients with Chronic Hypertension

  AUTHORS: Yu Cai, Jianjun Zhai, Bibo Feng, Rui Chen, Xingyue Tian

  KEYWORDS: Pregnancy with Chronic Hypertension, Aspirin, Maternal and Fetal Outcomes, ET-1, TM

  JOURNAL NAME: Open Journal of Obstetrics and Gynecology, Vol.11 No.8, August 27, 2021

  ABSTRACT: Objective: To investigate the effect of aspirin on pregnancy outcome and serum levels of endothelin-1 (ET-1) and thrombomodulin (TM) in pregnancy patients with chronic hypertension. Methods: Selected patients with chronic hypertension (mild to moderate) during pregnancy, who were enrolled and delivered in the Beijing Tongren Hospital Department of Obstetrics and Gynecology between January 1, 2019 and December 30, 2020. The patients were randomly divided into control group (60) and experimental group (60). The control group was treated with labetalol and the test group was treated with labetalol and aspirin. The therapeutic effect and pregnancy outcome of the two groups were compared. The serum levels of ET-1 and TM were measured before treatment and one week after treatment. Results: Systolic blood pressure (SBP) decreased significantly one week after treatment in the two groups (P Conclusion: Besides routine treatment, aspirin can improve the outcome of pregnant women with chronic hypertension, which may be related to the regulation of ET-1 and TM by aspirin.