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Varadi, A., Marrone, G.F., Palmer, T.C., Narayan, A., Szabó, M.R., LeRouzic, V., Grinell, S.G., Subrath, J.J., Warner, E, Kalra, S., Hunkele, A., Pagirsky, J., Eans, S.O., Medina, J.M., Xu, J., Pan, Y.-X., Borics, A., Pasterrak, G.W., MacLaughlin, J.P. and Majumderar, S. (2017) Mitragynine/Corynantheidine Pseudoindoxyls as Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2. Journal of Medicinal Chemistry, 59, 8381-8397.
https://doi.org/10.1021/acs.jmedchem.6b00748
has been cited by the following article:
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TITLE:
Novel Tandem Three Consecutive Reactions: Aza-Wittig, Imine Condensation and Electrophilic Aromatic Substitution Strategy to Indolizine Synthesis
AUTHORS:
Julio C. González-Rodríguez, Carlos González-Romero, Erick Cuevas-Yáñez, Juan J. Mejía Vega, Christopher K. Jankowski, David Corona-Becerril
KEYWORDS:
Iminophosphorane, Tandem Reaction, Indolizine Synthesis
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.11 No.2,
June
30,
2021
ABSTRACT: Reaction of ethyl
(Z)-3-(heteroaryl/aryl)-2-((triphenyl-λ5-phosphaneylidene) amino) acrylates
intermediates with 2,3-thiophenedicarboxaldehyde
was used in novel Tandem three
consecutive reactions: aza-Wittig, imine condensation and electrophilic heteroaromatic cyclization to obtain a series of
indolizines. A tentative mechanism of this reaction is proposed.