TITLE:
Ethnobotany, Pharmacology and Phytochemical Investigations of the Seeds of Pentaclethra macrophylla Benth (Mimosaceae)
AUTHORS:
Pierre V. K. Sinda, Beaudelaire K. Ponou, Borice T. Tsafack, Jonas Kühlborn, Roland T. Tchuenguem, Rémy B. Teponno, Jean P. Dzoyem, Till Opatz, Léon A. Tapondjou
KEYWORDS:
Pentaclethra macrophylla, Ethnobotany, Pharmacology, Aromatic Monoterpenoids, Chemophenetic Significance, Antimicrobial Activity
JOURNAL NAME:
Advances in Biological Chemistry,
Vol.11 No.3,
June
17,
2021
ABSTRACT: Phytochemical investigation of the seeds
of Pentaclethra macrophylla led to the isolation of a mixture of two new aromatic monoterpene
glycosides, pentamacrophylloside A
(1a) and pentamacrophylloside B (1b),
together with six known secondary
metabolites: Comososide (2), secopentaclethroside (3), caffeoylputrescine (4), β-sitosterol-3-O-β-D-glucopyranoside (5),2-hydroxymethyl-5-(2-hydroxypropan-2-yl)phenol
(6), and sucrose (7). Their structures were elucidated mainly by extensive spectroscopic analysis (1D and
2D NMR), high-resolution mass
spectrometry and by comparison of their
spectral data with those of related compounds. The extracts and compounds 3 and 4 were screened for their antimicrobial activity. The n-BuOH
fraction showed a weak effect against three microbial strains: Candida albicans (MIC: 256 μg/mL), Enterococcus faecalis (MIC: 512 μg/mL), and Proteus
mirabilis (MIC: 512 μg/mL) while
no significant inhibition was observed for pure compounds when compared to ketoconazole and ciprofloxacin used as references. Furthermore, the
ethnobotany and pharmacology of this plant are reviewed, and the chemophenetic significance of the isolation of
the above secondary metabolites is discussed. This is the first report on the isolation of aromatic
monoterpenoids from a plant of the genus Pentaclethra.