Nakagawa, H., Hasumi, K., Woo, J.T., Nagai, K. and Wachi, M. (2004) Generation of Hydrogen Peroxide Primarily Contributes to the Induction of Fe(II)—Dependent Apoptosis in Jurkat Cells by (-)-Epigallocatechin Gallate. Carcinogenesis, 25, 1567-1574.
https://doi.org/10.1093/carcin/bgh168

has been cited by the following article:

• TITLE: EGCG-S Impacts Oxidative Stress and Infection of Enterovirus 69 in Lung Cells

  AUTHORS: Hager Mohamed, Lee H. Lee, Sandra D. Adams

  KEYWORDS: ROS, Enterovirus 69, Picornavirus, Green Tea Flavanol, Antioxidant, Antivi-ral, MRC-5 Cells, A549 Cells

  JOURNAL NAME: Advances in Bioscience and Biotechnology, Vol.12 No.5, May 28, 2021

  ABSTRACT: Enteroviruses are responsible for emerging diseases which cause diverse symptoms and may result in neurological complications. An antiviral with multiple mechanisms of action can help prevent enterovirus mediated disease despite differences in the pathogenesis between enteroviruses, including the recently identified enterovirus 69 (EV-69) for which pathogenesis is not well understood. This study investigated the efficacy of epigallocatechin-3-gallate stearate (EGCG-S), a modified form of the antioxidant green tea catechin epigallocatechin-3-gallate (EGCG), in inhibiting EV-69 infection of lung fibroblast cells in vitro. Treatment with EGCG-S resulted in moderate protection from EV-69 mediated cytotoxicity as demonstrated by increased metabolic activity as well as maintenance of cell morphology and mitochondrial function. These effects were correlated with reduced hydrogen peroxide production in infected cells following EGCG-S treatment with concentrations less than 100 μM, suggesting a role for inhibition of EV-69 mediated oxidative stress. This study provides insight into characteristics of EV-69 infection as well as the efficacy of EGCG-S mediated inhibition of EV-69 infection.