TITLE:
A Novel Technique to Validate Dosimetry for Single-Isocenter Multiple-Target VMAT Stereotactic Radiosurgery
AUTHORS:
Yulin Song, Miao Zhang, Laszlo Voros, Xiaoli Tang, Ziad Saleh, Weixing Cai, Jeho Jeong, Boris Mueller, Borys Mychalczak
KEYWORDS:
Brain Metastasis, VMAT, SRS, WBRT, Film Dosimetry
JOURNAL NAME:
International Journal of Medical Physics, Clinical Engineering and Radiation Oncology,
Vol.10 No.2,
May
24,
2021
ABSTRACT:
Each
year, 170,000 cancer patients in the United States develop brain metastases.
Many of them present with multiple small lesions. Historically, Linac-based
stereotactic radiosurgery (SRS) was used to treat single solitary brain
metastasis with a diameter of less than 3.0 cm, while whole brain radiation
therapy (WBRT) was used to treat multiple brain metastases mainly as palliative
therapy. Evidence-based practices reveal that WBRT results in poor treatment
outcomes, with high local recurrence rates, decreased cognitive function, and
even the onset of dementia. Recently, volumetric modulated arc therapy (VMAT)
SRS has been tested as an alternative treatment to WBRT. Owing to its inherent
complexity and high risk, it is imperative to perform rigorous testing prior to
its clinical implementation. In this paper, we present a novel technique for
dosimetry validation of VMAT SRS.