Castan, P., Rodriguez, E.C., Beauchamp, A.L., Cros, S. and Wimmer, S. (1990) Platinum and Palladium Complexes of 3-Methyl Orotic Acid: A Route toward Palladium Complexes with Good Antitumor Activity. Journal of Inorganic Biochemistry, 38, 225-239.
https://doi.org/10.1016/0162-0134(90)84015-H

has been cited by the following article:

• TITLE: Synthesis, Molecular Spectroscopy, Computational, Thermal Analysis and Biological Activity of Some Orotic Acid Complexes

  AUTHORS: Mamdouh S. Masoud, Alaa E. Ali, Ashimaa S. Abd Elfatah, Gomaa E. Amer

  KEYWORDS: Orotic Acid, Synthesis, Complexes, Characterization, Thermal Analysis, Biological Activity

  JOURNAL NAME: Open Journal of Inorganic Non-metallic Materials, Vol.11 No.1, January 30, 2021

  ABSTRACT: Binary orotic acid metal complexes of Fe(III), Co(II), Ni(II), Cu(II), Zn(II), Cd(II), Hg(II), and two mixed metals complexes of (Co(II), Ni(II)) and (Ni(II), Cu(II)) were synthesized and characterized by elemental analysis, IR, electronic spectra, magnetic susceptibility, and ESR spectra. The Analysis proved that the ligand has different coordination modes and the complexes were of octahedral, tetrahedral, and trigonal bipyramidal geometries. Molecular modeling techniques and quantum chemical methods have been performed for orotic acid to calculate charges, bond lengths, bond angles, dihedral angles, electronegativity (χ), chemical potential (μ), global hardness (η), softness (σ) and the electrophilicity index (ω). The thermal decomposition of the complexes was monitored by TGA, DTA, and DSC techniques under the N2 atmosphere. The thermal decomposition mechanisms of the complexes were suggested. The biological activity of orotic acid and some of the complexes are tested against antibacterial and antifungal organisms.