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has been cited by the following article:

• TITLE: 3-(Tetrazol-5-yl)-2-imino-coumarins Derivatives: Synthesis, Characterization, and Evaluation on Tumor Cell Lines

  AUTHORS: Ali Bouattour, Mehdi Fakhfakh, Souhir Abid El-Gharbi, Majdi Abid, Ludovic Paquin, Rémy Le Guevel, Thierry Charlier, Houcine Ammar, Jean-Pierre Bazureau

  KEYWORDS: 2-Iminocoumarin, Tetrazole, Fluorescence, Tumor Cell Lines, HCT 116

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.11 No.1, March 9, 2021

  ABSTRACT: The first report of new 3-(tetrazol-5-yl)-2-iminocoumarin derivatives is described. The title compounds were prepared in two steps and were obtained in good yields (55-93%). They have been fully characterized by 1H, 13C NMR, FTIR, UV-Visible and HRMS. They were tested for their antiproliferative activities against six representative human tumor cell lines (Huh 7-D12, Caco2, MDA-MB231, HCT 116, PC3 and NCI-H727) and HaCat keratinocytes. Among them, compound 5e was active on HCT 116 (IC50 15 μM).