Huang, X., Zhen, J., Dong, S., Zhang, H., Van Halm-Lutterodt, N. and Yuan, L. (2019) DHA and Vitamin E Antagonized the Aβ 25-35-Mediated Neuron Oxidative Damage through Activation of Nrf2 Signaling Pathways and Regulation of CD36, SRB1and FABP5 Expression in PC12 Cells. Food and Function, 10, 1049-1061.
https://doi.org/10.1039/C8FO01713A

has been cited by the following article:

• TITLE: Small Molecular Weight Compounds Antagonistic to Amyloid Peptide25-35

  AUTHORS: W. Robert Williams

  KEYWORDS: Alzheimer’s Disease, Beta-Amyloid Peptide, Beta-Amyloid Antagonists, Molecular Modeling

  JOURNAL NAME: Journal of Biosciences and Medicines, Vol.9 No.1, January 21, 2021

  ABSTRACT: High levels of the neurotoxic beta-amyloid protein (Aβ) in patients with Alzheimer’s disease present a significant therapeutic target, although the protein is unlikely to be the sole instigator of this condition. Aβ initiates cell receptor and synapse dysfunction, and causes mitochondrial damage within neurons. Neurotransmitters and various small molecular weight compounds ameliorate the effects of Aβ on cell membranes. This study uses a molecular modeling technique to compare the structures of Aβ25-35 and compounds known to antagonize properties of the polypeptide. Compounds provide good fits to the peptide amino acid residues, revealing planarity in their linear structures and fitting points. Compounds and polypeptide share relative molecular similarity, affinity for receptors and apoptosis modulating properties indicative of their potential for competition at neuron membrane sites. The therapeutic targeting of Aβ by small molecular weight compounds may benefit from a multi-drug approach.