TITLE:
The Prediction Value of the Infection Probability Score (IPS) Combined with Serum Cholinesterase and D-Dimer Detection for Infection and Survival in Critically Ill Patients
AUTHORS:
Qian Zhao, Huijun Qi, Hui Guo, Zhangshun Shen, Jianguo Li
KEYWORDS:
Critical Illness, Infection, Infection Probability Score (IPS), Cholinesterase, D-Dimer, Survival Prognosis
JOURNAL NAME:
Case Reports in Clinical Medicine,
Vol.9 No.8,
August
20,
2020
ABSTRACT: Objective: To evaluate early prediction value of IPS combined with SchE and D-dimer detection for
infection and survival in critically ill patients. Methods: 199 critically ill patients admitted to the
emergency intensive care unit (EICU) of our hospital from December 2018 to
December 2019 were retrospectively analyzed, including 110 infection patients
(infection group) and 89 non-infection patients (non-infection group). According to the survival,
the infection group was divided into death group (68 cases) and survival group
(42 cases). The IPS, APACHE II, SOFA and SchE, D-dimer expression levels were
detected and compared; Univariate and logistic regression analysis were used to
evaluate the independent prognostic factors. Results: The IPS and APACHE
II of patients in the infected group were higher than those in the non-infected
group, the level of SchE was lower than that in the non-infected group, and the
level of D-dimer was higher than that in the non-infected group (P 0.001). IPS, SOFA, APACHE II, SchE, D-dimer, invasive mechanical ventilation, septic shock, and ICU
length of stay had significant influence on the prognosis
of critically ill patients (P 0.001). Logistic
regression analysis showed that IPS (OR = 2.821, 95% CI 1.501 - 5.227), SOFA (OR = 5.078, 95% CI 3.327 - 7.690), APACHE II (OR = 14.308, 95% CI 8.901 - 21.893), SchE (OR = 0.223, 95% CI 0.165 - 0.291), D-dimer (OR = 2.10, 95% CI 1.55 - 2.85), septic shock (OR = 9.948, 95% CI 7.012 - 17.012) were independent factors
affecting the prognosis of critically ill patients with infection (P 0.001). Conclusion: IPS and D-dimer expression level in infected
patients were increased and SchE decreased significantly compared with those in
non-infected patients, and they significantly correlated with disease severity of
infected patients and could be early
prediction for prognosis.