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https://doi.org/10.1117/1.JBO.24.5.056007

has been cited by the following article:

• TITLE: An Antibacterial Wound Dressing Based on GS-SF Composite Scaffold

  AUTHORS: Qifeng Jiang, Ping Chen, Bin Gao

  KEYWORDS: Silk Fibroin, Gentamicin Sulfate, Wound Dressing, Anti-Bacterial

  JOURNAL NAME: Health, Vol.12 No.8, August 10, 2020

  ABSTRACT: Although the treatment of burn wounds has made great progress, the incidence of wound infection is still the main cause of high mortality. In this study, a silk fibroin (SF) scaffold wound dressing incorporated with Gentamicin Sulfate (GS) was developed for the treatment of burn infected wounds, in which GS was used as anti-bacterial agent. GS was mixed with silk fibroin solution and then processed into GS-SF composite scaffold via electro-spinning. The results showed the scaffold exhibited uniform polyporous morphology with 80% porosity. Induced by methanol, the scaffold presented much improved mechanical properties and stability to protease XIV. More important, the scaffold presented significant growth inhibition on both Gram-positive (Staphylococcus aureus) and Gram-negative (Pseudomonas aeruginosa and Escherichia coli) bacteria.