TITLE:
Efficacy of Isotonic Seawater Solution on Inflammation of the Ocular Surface in Matrix Metalloproteinase MMP-9-Positive Dry Eye Disease Patients
AUTHORS:
Diaz-Llopis Manuel, Pinazo-Duran Maria Dolores, Diaz-Guiñon Loreto, Rahhal-Ortuño Miriam, Gallego-Pinazo Roberto, Dolz-Marco Rosa, Diaz-Guiñon Teresa, Diaz Maria, Romero Francisco Javier
KEYWORDS:
Dry Eye, Inflammadry Test, MMP-9, Ocular Surface Inflammation, Ophthal-mic Isotonic Seawater Solution
JOURNAL NAME:
Open Journal of Ophthalmology,
Vol.10 No.3,
August
6,
2020
ABSTRACT: Purpose: Prospective study to evaluate the anti-inflammatory efficacy of isotonic
seawater solution on metalloproteinase 9 (MMP-9) levels in the tears of
patients with dry eye disease (DED). Methods: A total of 50 patients
were included, with the following dry eye criteria in both eyes: InflammaDry? test initially positive, ocular surface disease
index (OSDI) score ≥ 12 and Results: The InflammaDry test was
positive in 100% of the patients (n = 50) and in 100% (n = 100) of the eyes
before treatment. In 14 (28%) patients the test became negative in both eyes,
and in 15 (30%) it was negative in one of the eyes. In 43% (n = 43) of the
positive eyes, MMP-9 became undetectable in the tear fluid following treatment
with isotonic seawater. This change was statistically significant (p Conclusions: The washes with ophthalmic isotonic seawater
solution have a significant impact on inflammation of the ocular surface in dry
eye disease, with an ability to make MMP-9 levels negative in 43% of cases.