TITLE:
Treatment Strategy for Post-Hepatectomy Recurrent Hepatocellular Carcinoma: A Single Center Experience with 556 Consecutive Cases in China
AUTHORS:
Jing Li, Liang Huang, Caifeng Liu, Maixuan Qiu, Jianjun Yan, Shaohua Wei, Yiqun Yan
KEYWORDS:
Post-Hepatectomy Recurrent Hepatocellular Carcinoma, Clinical Classification, Treatment Strategy, Clinical Outcomes
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.11 No.7,
July
15,
2020
ABSTRACT: Background: Treatment strategy for recurrent hepatocellular carcinoma (HCC) remains
scantily defined. This study was aimed to establish a treatment strategy to
manage post-hepatectomy recurrent HCC and report the clinical outcomes. Methods: From January 2006 to December 2016, 556 consecutive patients who developed
post-hepatectomy HCC recurrence were enrolled in the study. The patients were
clinically stratified and treated according to a strategy established by a
multi-disciplinary team. Clinical data and survival times were collected
prospectively and analyzed retrospectively. Results: According to the
strategy, there were 298 (53.6%), 214 (38.5%), 32 (5.7%) and 12 (2.2%) patients
stratified into Early, Intermediate, Advanced and Terminal stages,
respectively. In Early stage patients, 164 (55.0%) received curative treatment
in the form of repeat resection or local ablation, 134 (45.0%) received
transarterial chemoembolization (TACE), and
the 1-, 3-, and 5-year overall survival (OS) rates were 82.0%, 46.8% and 37.3%,
respectively. In Intermediate stage patients, 207 (96.7%) received TACE, 7 (3.3%)
radiotherapy, and the 1-, 3-, and 5-year OS rates were 73.2%, 31.8% and 15.9%, respectively.
In Advanced stage patients, 22 patients received sorafenib, 10 radiotherapy,
and the mean survival time (MST) was 25.1 ± 3.1 months. All the 12 patients in Terminal
stage received the best supportive treatment, and the MST was 6.5 ± 3.4
months. Clinical stages and duration of disease-free interval were independent
factors relating to overall survival. Conclusions: A treatment strategy
derived from the Barcelona Clinic Liver Cancer staging system, with some
modifications, has been successfully established to manage post-hepatectomy
recurrent HCC, and the clinical outcomes were commendable.