TITLE:
Acetylation of Starch Extracted from Rejected Fruits of Musa × paradisiaca L. to Obtain a Pharmaceutical Disintegrant
AUTHORS:
Karla Dumancela, Eduardo Mayorga, Javier Santamaría- Aguirre
KEYWORDS:
Modified Banana Starch, Acetylation, Swelling Capacity, Disintegrant, Dissolution Profile
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.11 No.6,
June
29,
2020
ABSTRACT: There are many natural sources to obtain
pharmaceutical grade starch, one of which is banana (Musa × paradisiaca L.); nevertheless, the use of native starch
has certain disadvantages compared to modified starches, whose disintegrating
properties are better. In this study, starch extracted from rejected fruits of Musa × paradisiaca L., was modified by acetylation, under the
following optimized experimental conditions: 130 mL acetic anhydride, 3 mL
sodium hydroxide 50% p/v for each 15 grams of native starch, at 123℃ during 3
hours. The reaction resulted in a modified green banana starch with twice as
much swelling capacity compared to unmodified (native) starch; acetylation was
verified by infrared spectroscopy and degree of substitution of acetyl groups by
back titration. The dissolution profiles of Ibuprofen tablets made with banana modified starch and commercial disintegrant,
have no differences according with their similarity factor, f2. It is concluded that it is feasible to use green
banana starch modified through acetylation as a pharmaceutical disintegrant.